Molecular Determinants of Coronaruy Artery Disease

Genetic Studies of Coronary Artery Disease and Arteriovenous Malformation (GeneQuest) Molecular Determinants of Coronary Artery Disease

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00590291

Acronym

GeneQuest

Enrollment

1461

Registered

2008-01-10

Start date

1995-01-31

Completion date

2021-04-01

Last updated

2021-05-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arteriovenous Malformations, Coronary Artery Disease, Myocardial Infarction

Keywords

Coronary Artery Disease, Arteriovenous Malformations, Myocardial Infarction, CAD, MI, Heart Attack, AVM, genetic, familial

Brief summary

The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM).

Detailed description

The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM). Many human diseases are inherited or passed from parent to child in families. These diseases occur because of damage to a gene(s), the genetic material that is also called DNA. Scientists can now use modern molecular techniques to locate and to find certain genes within the DNA (genetic material) of a person, and to follow their inheritance in a family. To find these disease-causing genes requires studies of many affected with the disease and their family members. The purpose of this study is to locate and to find the genes for coronary artery disease (CAD) which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages; or, arteriovenous malformation (AVM) which causes abnormal vascular connections between arteries and veins, particularly near the heart. Findings of the genes causing CAD and AVM will have far-reaching effect on the diagnosis, treatment, and prevention of coronary artery disease and arteriovenous malformation. These studies will lead to possible genetic diagnosis, early detection of persons at risk for developing CAD or AVM (even in the absence of symptoms), development of effective drugs, more rational and specific therapeutic interventions, treatments and ultimately, prevention of coronary heart disease. Approximately 3-5 years are required to find one human disease gene.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Males at least 45 years old and premenopausal females at least 50 years old at the time of onset of any of the following: * PTCA * MI * CABG * Must have a living sibling meeting the same criteria.

Exclusion criteria

* Substance Abuse in the absence of angiographic coronary stenosis * Congenital Heart Disease

Design outcomes

Primary

Measure	Time frame
Coronary Artery Disease	2009
Arteriovenous Malformation	2009

Secondary

Measure	Time frame
Myocardial Infarction	2009

Countries

United States

Outcome results