Impact of Diet and/or Exercise-induced Weight Loss on Cardiovascular Risk Factors

Longitudinal Impact of Diet and/or Exercise-induced Weight Loss on Metabolic Markers of Cardiovascular Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00588978

Enrollment

Registered

2008-01-09

Start date

2003-08-01

Completion date

2008-12-01

Last updated

2020-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Keywords

c-reactive protein, obesity, women's cardiovascular health

Brief summary

The purpose of this pilot study is to examine the effect of diet and/or exercise-induced weight loss on nontraditional cardiovascular risk factors such as c-reactive protein, insulin levels and sex steroids in obese postmenopausal women.

Interventions

BEHAVIORALdiet and/or exercise

Three arms are included: Diet Alone, Exercise Alone, and Combined Diet and Exercise

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

40 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* obese postmenopausal women * able to exercise * non-smokers

Exclusion criteria

* cardiovascular disease * medications that would interfere with outcome measures (e.g., including ACE inhibitors, lipid lowering medications, beta-blockers, etc) * known diabetes

Design outcomes

Primary

Measure	Time frame
c-reactive protein	baseline, every 1-2 weeks during intervention , then end-of-study

Secondary

Measure	Time frame
HOMA (measure of insulin resistance) and sex steroids	baseline, every 1-2 weeks during intervention, then end-of-study

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026