Effect of Remifentanil, Movement Disorders
Conditions
Keywords
Deep Brain Stimulation, Movement Disorders, Remifentanil, Sedation, Basal Ganglia electrical activity
Brief summary
Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who has to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the basal ganglia. The purpose of this study is to detect possible changes in the electrical activity of the basal ganglia related to remifentanil sedation. electrical activity of single neurons will be recorded before, during and after sedation.
Interventions
DRUGRemifentanil
After the mapping electrode is in situ, recording of baseline electrical activity is done for two-three minutes and an infusion of Remifentanil, 0.1 microgram per kilogram per minute is started. This procedure continues for a few minutes until the patient is sedated and then the infusion is stopped and the patient allowed to recover. The recordings continue during the whole procedure.
Sponsors
Hadassah Medical Organization
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with movement disorder, who are candidates for implantation of deep brain stimulation electrode.
Exclusion criteria
* Suspected difficult intubation * history of sleep apnea * known allergy for remifentanil
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electrical activity in the basal ganglia | During the experiment |
Outcome results
None listed