Embryo Implantation, Infertility
Conditions
Brief summary
Hypothesis: a special solution for improving human embryo implantation, when added to the solution during embryo transfer, will improve implantation rates in embryo transfers using previously frozen embryos.
Detailed description
EmbryoGlue (TM) is added to embryo transfer solutions immediately prior to the transfer of frozen-thawed human embryos before placement of embryos into the patient uterus.
Interventions
OTHEREmbryoGlue
G2 culture media from Vitrolife which contains hyaluronic acid
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Frozen embryo transfer patients, men over the age of 18 and women between the ages of 18 and 42 completed years (if using their own eggs and with embryos frozen before 39 completed years) or 18 to 50 completed years if using donated eggs.
Exclusion criteria
* Prior participation in this study, blastocyst transfers, single embryo transfer for medical reasons, prior embryo transfer with large amount of blood on the outside of the catheter, \> or = 3 consecutive failed embryo transfers at Mayo Clinic (fresh or frozen-thawed cycles).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy Rate | one month |
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate | two months |
Countries
United States
Outcome results
None listed