Aortic Distensibility

ECG-Gated Multidetector CT of Aortic Distensibility FAMRI

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00587977

Acronym

FAMRI

Enrollment

Registered

2008-01-08

Start date

2004-11-30

Completion date

2009-07-31

Last updated

2012-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Aortic Aneurysm

Keywords

Abdominal aortic aneurysm

Brief summary

Can software be developed to automatically aid in the measurement of abdominal aortic aneurysms, and is there a way to predict future rupture or growth of abdominal aortic aneurysms.

Detailed description

Hypothesis: ECG-gated multidetector CT and ECG-gated Dual Source CT can be used to create multiple volumetric datasets of the abdominal aorta over the time period of the cardiac cycle, allowing for direct and regional calculations of abdominal aortic distensibility over the entire volume of the abdominal aorta, providing insight into risk of abdominal aortic aneurysm rupture and early large vessel stiffness.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* AAA must be at least 3 cm to a maximum 4.9cm cross-sectional diameter. * BMI 31 or less. * Creatinine results \<2.0 and within six months prior to scan. * US patients must have only normal creatinine (0.9 to 1.4) for one year before study visit. * Patients who are originally scheduled for US, who are then subsequently rolled in this study, will have only a ultrasound scan as followup after the initial CTA.

Exclusion criteria

* Creatinine \> 2.0. * Creatinine \<0.9 or \>1.4 for those who are scheduled for US. * Atrial fibrillation or other arrythmia. * Known AAA greater than 5 cm in size. * Allergy to contrast dye.

Design outcomes

Primary

Measure	Time frame
In year one, this data will be used to develop pulsatility software and test robustness.	First Year

Secondary

Measure	Time frame
In year two, the time-resolved CT angiographic datasets from each patient will be analyzed to determine peak AAA pulsatility and peak AAA relative pulsatility (to cross-sectional area within the aneurysm).	Year Two

Countries

United States

Outcome results