Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00587535

Enrollment

Registered

2008-01-07

Start date

2003-08-31

Completion date

2011-07-31

Last updated

2016-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemochromatosis

Keywords

hemochromatosis, liver cirrhosis, liver diseases

Brief summary

The purpose of this study is to determine if a new MR pulse sequence is accurate in determining how much iron is in the liver.

Detailed description

Quantification of liver iron requires liver biopsy and histological assessment. New rapid MR techniques allow determination of liver relaxation times that can be altered with increasing iron deposition. The purpose of this study is to compare the results obtained with MRI to liver biopsy and iron quantification in patients undergoing liver biopsy in the setting of hemochromatosis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Undergoing liver biopsy for suspected or known hemochromatosis * Undergoing liver biopsy for living-related liver donation evaluation

Exclusion criteria

* Contraindication to MRI

Design outcomes

Primary

Measure	Time frame
Accuracy of MR in quantifying liver iron	one time point

Countries

United States

Outcome results