Barrett's Esophagus, Early Esophageal Adenocarcinoma
Conditions
Keywords
Photodynamic Therapy, Barrett's Esophagus, Early Esophageal Adenocarcinoma
Brief summary
To assess the effect of ablative therapy (Photodynamic Therapy or Radiofrequency ablation ) on Barrett's Esophagus
Detailed description
To assess the effect of ablation therapy on Barrett's esophagus. Proposal Ablation therapy is an FDA approved treatment to decrease cancer risk in Barrett's esophagus mucosa. This is being performed in our Barrett's Esophagus Unit on a regular basis. However, the longterm outcomes of this therapy is not established and there are patients who have been treated who later re-develop Barrett's mucosa. This study will allow us store tissue samples that can later be used to assess the effect of ablative therapy on Barrett's esophagus.
Interventions
OTHERBiopsy
Biopsies for research purposes will be obtained when returning for clinically indicated surveillance of Barrett's Esophagus
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients who have had or qualify for ablation therapy for treatment of their barrett's esophagus with high grade dysplasia or early esophageal adenocarcinoma * Ability to provide informed consent
Exclusion criteria
* Eastern Cooperative Oncology Group performance status 3 or 4 * Inability to tolerate endoscopic procedures * Pregnancy: Females of child-bearing age will be screened with pregnancy test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response to treatment | at time of surveillance intervals | presence of persistent or recurrence of barrett's esophagus and/or dysplasia |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORCadman Leggett, MD
Mayo Clinic
Outcome results
None listed