Coronary Disease, Fatty Acids, Unsaturated, Hemodialysis, Radioisotopes, Single Photon Emission Computed Tomography
Conditions
Keywords
Myocardial Free Fatty Acid metabolism, High risk patients, End-stage renal failure, Cardiovascular events, prognosis
Brief summary
The aim of this multi-center study is to determine the applicability of BMIPP to diagnosing cardiac disease and to predicting the outcome of patients on hemodialysis.
Interventions
None listed
Sponsors
Toho University Ohashi Medical Center
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult hemodialysis patients with one or more of the following 10 risk factors for coronary heart disease * Hypertension * Diabetes mellitus * Hyperlipidemia * Obliterative arteriosclerosis in the lower extremities * Smoker * Family history of juvenile coronary artery disease * History of ischemic stroke * History of heart failure requiring hospitalization * Within 3 months after initiation of hemodialysis therapy * Dialysis hypotension
Exclusion criteria
Hemodialysis patients who meet any one of the following conditions will be excluded. * Peritoneal dialysis * Severe valvular disorder requiring treatment * Diagnosis of hypertrophic cardiomyopathy(HCM) or dilated cardiomyopathy(DCM) before start of dialysis * History of revascularization(PCI, CABG) or prior diagnosis of myocardial infarction * Hypersensitivity to BMIPP or its analogue * Judged unsuitable for the study for any other reasons by physicians.
Countries
Japan
Outcome results
None listed