Vascular Effects of Sertraline in Heart Failure

Effects of Chronic Sertraline Hydrochloride Administration on Vascular Endothelial and Autonomic Function in Patients With Chronic Heart Failure

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00585455

Enrollment

Registered

2008-01-03

Start date

2006-01-31

Completion date

2009-07-31

Last updated

2009-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Heart Failure

Keywords

vascular endothelium, nitric oxide, depression, heart failure, vascular biology

Brief summary

To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression

Interventions

DRUGsertraline

open label 25-50 mg daily as tolerated

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Inclusion criteria

* Chronic heart failure with LVEF\<40%, age \>21 years * Depression requiring medical treatment with sertraline

Exclusion criteria

* Known intolerance of sertraline

Design outcomes

Primary

Measure	Time frame
Brachial artery flow-mediated dilation	2 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026