Gastroesophageal Reflux Disease
Conditions
Keywords
GERD, laryngopharyngeal reflux disease
Brief summary
Involves a 24-hour pH probe study using the Dx-pH Measurement System on patients who do not have symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease to establish normal values for the Dx-pH Measurement System.
Detailed description
The specific aim of this study is to establish the normal range of values in an adult population with no symptoms of laryngopharyngeal reflux disease or gastroesophageal reflux disease using the Dx-pH Measurement System.
Interventions
DEVICEDx-pH Measurement Probe
Dx-pH Measurement Probe measures gaseous pH values in the nasopharynx and oropharynx over a period of 24 hours.
Sponsors
University of California, Davis
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years of age or older * no symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease * score less than 10 on Reflux Symptom Index
Exclusion criteria
* age less than 18 * known lidocaine allergy * history of heartburn, regurgitation, chronic cough, voice changes, globus pharyngeus, excessive throat clearing, or swallowing problems * score 10 or greater on Reflux Symptom Index * current or past antacid use or other antireflux therapy * history of antireflux surgery * pregnancy * current anticoagulation therapy (warfarin, heparin, aspirin, clopidogrel bisulfate) * special/vulnerable populations (children, mentally handicapped, pregnant women, fetuses, prisoners, cognitive impairment, life-threatening disease, social or economic disadvantage)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To develop a range of normal values in adults without symptoms of laryngopharyngeal reflux. | At completion of study |
Countries
United States
Outcome results
None listed