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Using Dexamethasone After Uvulopalatopharyngoplasty

Decreasing Morbidity After Uvulopalatopharyngoplasty With the Use of Dexamethasone - A Randomized Double Blinded Placebo Controlled Trial

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00584168
Enrollment
15
Registered
2008-01-02
Start date
2005-03-31
Completion date
2011-12-31
Last updated
2012-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

UPPP, Dexamethasone, Uvulopalatopharyngoplasty, Pain Management, Increasing pain management in patients that have undergone UPPP surgery

Brief summary

This study looks at lessening the pain after a Uvulopalatopharyngoplasty (UPPP) surgery by using Dexamethasone (a corticosteroid).

Detailed description

The study was designed because patients have a lot of pain after they have a UPPP. Certain drugs called steroids may lessen the pain associated from this surgery. This study uses Dexamethasone (a corticosteroid), to see if it will help reduce pain, decrease the amount of time until the patient can begin to eat or return to normal activity, or increase their satisfaction with pain management. In this study the patients will be randomized (computer chosen) to receive either the study drug (dexamethasone), or a placebo. The patient will start the day before surgery with a single pill. They will then receive the dexamethasone or a placebo twice daily for the next four days and then once daily for the next two days for a total of seven days. Afterward, they will be asked to complete a questionnaire. The five questions ask patients to access the amount of pain they have, how much of their normal diet or activity they have returned to, and how much pain medication they have taken. At the next follow-up visit they will be asked to complete another questionaire (9 questions) about the patient's satisfaction with pain management.

Interventions

DRUGDexamethasone

They will take a pill the day before surgery, twice daily for the next four days and then once daily for the next two days for a total of seven days.

DRUGPlacebo

They will take a pill the day before surgery, twice daily for the next four days and then once daily for the next two days for a total of seven days.

Sponsors

University of Oklahoma
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Candidates scheduled for UPPP surgery. * Able to take steroids

Exclusion criteria

* Those patients who unable to take steroids

Design outcomes

Primary

MeasureTime frame
Quantifying patient treatment with a questionaire. Patient will rate their satisfaction with pain management.Eleven days post-operative

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026