Metabolic Syndrome, Nonalcoholic Steatohepatitis
Conditions
Keywords
leptin, leptin receptors, adiponectin
Brief summary
NAFLD is a spectrum of liver diseases associated with varying degrees of hepatic steatosis, inflammation, and in some cases, fibrosis. NAFLD is a common observation in all demographics, but the prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) is especially high in the morbidly obese population. Leptin is a cytokine that is encoded by the ob gene and primarily secreted by adipose tissue. The production of serum leptin increases with progressive obesity. Because of this observation, there has been significant interest in potential role of leptin in NAFLD. Our hypothesis is that we will find increased hepatic leptin and leptin receptor expression as the degree of hepatic injury worsens in NAFLD.
Interventions
OTHERno interventions, only regular blood-draw
No interventions, only regular blood-draw (liver biopsy obtained per routine during the surgery)
Sponsors
University of California, Davis
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* All patients undergoing elective bariatric surgery, ages 18-65.
Exclusion criteria
* non-obese patients, ages less than 18 and over 65. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To link SLR to grade/stage of NASH | 2.5 years |
Secondary
| Measure | Time frame |
|---|---|
| To link SLR, leptin and adiponectin to features/components of the metabolic syndrome | 2.5 years |
Countries
United States
Outcome results
None listed