Atrophy, Sepsis, Weakness
Conditions
Keywords
sepsis, atrophy, muscle, weakness
Brief summary
Severe sepsis will provoke signals leading to muscle atrophy and weakness. Electrical stimulation will reduce the impact of sepsis.
Detailed description
Hypothesis 1: Severe sepsis will be associated with downregulation of anabolic signaling molecules and genes, upregulation of catabolic signaling molecules and genes, and the development of histologic and electrophysiologic abnormalities within skeletal muscle. Hypothesis 2: Electrical stimulation will improve muscle strength in patients with sepsis. Hypothesis 3: Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes, and improvement of histologic and electrophysiologic parameters within skeletal muscle of patients with sepsis. Hypothesis 4: The ratio of catabolic:anabolic gene expression on Day 3 will be positively correlated with the severity of clinical weakness on Day 7
Interventions
None listed
Sponsors
Gregory A. Schmidt
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Severe sepsis for \< 72hr
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with sepsis | 3 days |
Secondary
| Measure | Time frame |
|---|---|
| Electrical stimulation will be associated with improvement of histologic and electrophysiologic and strength parameters within skeletal muscle of patients with sepsis | 7 days |
Countries
United States
Outcome results
None listed