Low Birth Weight, Periodontal Disease, Preterm Birth
Conditions
Keywords
Periodontal Disease, Preterm Birth, Low Birth Weight, Pregnancy
Brief summary
To determine the relationship between periodontal disease and upper genital tract inflammation in pregnancy. To determine whether certain fluid levels in the oral cavity and the vagina are associated with preterm birth or low-birth weight.
Detailed description
Patients will be enrolled in the study at their first prenatal visit after the details of the study have been discussed. Potential subjects will be presented with a questionnaire to determine eligibility for the study. The patient will be scheduled for an exam between 18-24 weeks at which time they will undergo a periodontal assessment, to determine the presence or absence of periodontal disease, a sampling of gingival crevicular fluid (GCF) and a vaginal swab collection. Periodontal disease will be determined by measuring the depth of gingival sulci, amount of periodontal attachment loss, and prevalence of gingival bleeding at six sites for each tooth present.
Interventions
None listed
Sponsors
University of Oklahoma
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
15 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Between the ages of 15-35 * Singleton gestation
Exclusion criteria
* Diabetes prior to pregnancy * Require antibiotic prophylaxis prior to dental treatment * Require steroids during pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the relationship between periodontal disease and upper genital tract inflammation as measured by cytokine levels IL-6, IL-1, and TNF-α and MMP levels from the posterior fornix of the vagina. | 4 years |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether IL-1β levels in the oral cavity and the vagina are associated with preterm birth or low-birth weight. | 4 years |
Countries
United States
Outcome results
None listed