Blood Pressure, Cardiac Transplantation
Conditions
Keywords
water, blood pressure, vascular resistance, cardiac transplantation
Brief summary
In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.
Detailed description
In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. We will test the hypothesis that water ingestion will increase the systemic vascular resistance. This study will occur in patients status post cardiac transplantation during their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs and plasma norepinephrine levels will be measured before and 30 min after the water ingestion.
Interventions
DIETARY_SUPPLEMENTwater
water 500 ml x 1
Sponsors
National Center for Research Resources (NCRR)
Satish R. Raj
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* s/p cardiac transplantation scheduled for clinical right heart catheterization * age \> 18 years
Exclusion criteria
* significant tricuspid regurgitation * inability to safely swallow 500 ml of water * other major medical comorbidities such as advanced renal disease where water ingestion may be harmful to patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in total vascular resistance | 40 min (before to 30 min after water ingestion | TPR measured by Modelflow |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | 40 min | peak BP over 40 min |
| heart rate | 40 min | HR at time of peak BP over 40 min |
| plasma norepinephrine | 40 minutes | plasma norepinephrine drawn 40 min post ingestion |
Countries
United States
Outcome results
None listed