Substance Abuse Disorder
Conditions
Keywords
Cocaine abstinence, PET scan
Brief summary
This study evaluates theories regarding cocaine abstinence which propose that increased presynaptic and postsynaptic dopamine activity and increased serotonin activity are associated with abstinence in cocaine dependent subjects at the beginning and three to six months after a treatment program. We are using positron emission tomography (PET), Magnetic Resonance Imaging (MRI) and diffusion tensor imaging (DTI) in cortical and subcortical areas in a series of brain imaging studies testing these theories of abnormalities in the dopamine and serotonin system for cocaine addiction by examining the distribution of 18F-fallypride, 18F-altanserin, and FDG. We are evaluating genetic theories associated with cocaine addiction through the examination of genetic markers and functional genomics.
Interventions
RADIATIONPET scan
positron emission tomography PET scan
OTHERfMRI
functional magnetic resonance imaging fMRI
Sponsors
US Department of Veterans Affairs
University of California, Irvine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria include: 1. Subjects must be male or female and English speaking. 2. Subjects must be adults with a history of diagnosis of cocaine dependence disorder (n=20) who are under supervised treatment for dependence or normal control (n=10). 3. Subjects must be between 21 to 65 years of age.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PET scans, fMRI scans | The beginning and three to six months after a treatment program |
Countries
United States
Outcome results
None listed