Orthostatic Hypotension
Conditions
Keywords
water, orthostatic hypotension, blood pressure
Brief summary
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.
Detailed description
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.
Interventions
OTHERwater high dose
water 16 oz PO x 1
OTHERwater tiny dose
water 1 oz PO x 1
Sponsors
Satish R. Raj
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* orthostatic hypotension (fall in BP\>20/10 mmHg) * pressor response to water in other studies * Age 18-80 years
Exclusion criteria
* pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure | 2nd water intervention |
Secondary
| Measure | Time frame |
|---|---|
| heart rate | 2nd intervention |
Countries
United States
Outcome results
None listed