Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00580918

Enrollment

Registered

2007-12-27

Start date

2003-10-31

Completion date

2003-10-31

Last updated

2021-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Traumatic Brain Injury

Keywords

Mild Traumatic Brain Injury, fMRI

Brief summary

The purpose of this study will be to assess the attentional ability of patients with mild to moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI) technique. Methodology for specific aim 1: sagittal pilot scan, 3-D anatomical MRI, Whole brain echo-planar imaging (EPI), and functional MRI techniques with traumatic brain injured subjects doing a Continuous Performance Test (CPT) attention task and compare the pattern of activation with those of normal controls to see if there is a failure to activate frontal lobes in the traumatic brain injured subjects.

Interventions

OTHERfunctional magnetic resonance imaging fMRI

functional magnetic resonance imaging fMRI

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Mild to moderate brain injury patients referred to the UCI Brain Imaging Center. * Mild brain injury patients will be defined as having a Glascow Coma Scale (GCS) scale of 13-15. * Moderate brain injury brain injury patients will be defined as having a Glascow Coma Scale (GCS) scale of 9-12 . * Normal healthy control subjects (20)

Exclusion criteria

* Pre-accident neuropathology, psychopathology, or secondary neuropathological complications, or chemical abuse * Patients who required intracranial surgical intervention * Children, pregnant women, or institutionalized individuals unable to freely give consent * Patients with implanted surgical clips (hemostatic clips) or other ferromagnetic material * Patients engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or who may have imbedded metal fragments from military activities * Patients with permanent (tattoo) eye-liner or with facial make-up (severe eye irritation has been reported) * Patients with metallic implants, because they may cause artifacts in diagnostic images due to magnetic field distortion * Patients with implanted prosthetic heart valves * Patients with pacemakers, neuro-stimulation devices * Subjects who have severe claustrophobia.

Design outcomes

Primary

Measure	Time frame
fMRI scans	three to four years post injury

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026