Non-cancer Affected Volunteers
Conditions
Keywords
non-cancer affected volunteers, aged 60 years or older
Brief summary
The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.
Detailed description
This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.
Interventions
OTHERSaliva or Blood samples
Extracting sample of saliva or blood only once.
Sponsors
Susan G. Komen Breast Cancer Foundation
Beth Abraham
Gurwin Jewish Nursing & Rehabilitation Center
Hebrew Home at Riverdale
Jewish Home & Hospital Lifecare System
Margaret Tietz Nursing and Rehabilitation Center
Metropolitan Jewish Health System
Northern Services Group
Parker Jewish Institute
Lenox Hill Neighborhood House
JASA at Temple Emanuel of Parkchester Senior Center
Van Cortlandt Village Senior Center
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation. * Subjects will self-identify religion and country of origin of grandparents. * Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.
Exclusion criteria
* Subjects with mental impairment will be excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly. | conclusion of the study |
Secondary
| Measure | Time frame |
|---|---|
| samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2. | conclusion of the study |
Countries
United States
Outcome results
None listed