Brain Vascular Disorders, Coronary Artery Disease
Conditions
Brief summary
To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.
Detailed description
The purpose of this study is to determine whether the intravenous microbubbles used to improve border delineation during dobutamine stress echocardiographies (DSE) can be detected within the cerebral circulation.
Interventions
PROCEDUREUltrasound on Temporal Bone
All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.
Sponsors
University of Nebraska
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* male or female age \>19 years of age * scheduled for a stress echocardiogram * negative urine pregnancy test within two hours of ultrasound contrast administration required for females of childbearing age unless post-menopausal or with evidence of surgical sterilization * be conscious and coherent, and able to communicate effectively with trial personnel
Exclusion criteria
* pregnant or lactation * life expectancy of less than 2 months or terminally ill * Known or suspected hypersensitivity to ultrasound contrast agent used for the study * complicated hemodynamic instability * Known left main disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detect abnormalities in cerebral blood flow | immediate | All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| if cerebral vascular disease is detected it would lead to further testing that may better identify abnormalities. | within 30 minutes | All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur. |
Outcome results
None listed