Cardiac Surgery, Elderly
Conditions
Brief summary
A total balanced fluid replacement strategy is a promising concept for correcting hypovolemia. The effects of a balanced fluid management including a new balanced hydroxyethylstarch (HES) in elderly cardiac surgery patients will be studied.
Interventions
DRUGBalanced HES 130/0.42
Volume is administered perioperatively and during the first 48 hrs after surgery when mean arterial pressure (MAP) was \<60mmHg and pulmonary capillary wedge pressure (PCWP) or central venous pressure (CVP) is \<10 mmHg
DRUG6% HES 130/0.4 prepared in saline solution
Volume will be administered perioperatively and during the first 48 hrs after surgery when mean arterial pressure (MAP) is \<60mmHg and pulmonary capillary wedge pressure (PCWP) or central venous pressure (CVP) is \<10 mmHg
Sponsors
Klinikum Ludwigshafen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
80 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged \>80 years
Exclusion criteria
* Chronic kidney dysfunction requiring dialysis * Myocardial infarction within the previous 3 weeks * Liver insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is postoperative renal function | 28 days |
Secondary
| Measure | Time frame |
|---|---|
| Other organ function (myocardial function, endothelial function, degree of inflammation) | Postoperative period |
Countries
Germany
Outcome results
None listed