FindTrial
Sign In

Aggressive Versus Moderate Glycemic Control in Diabetic Coronary Bypass Patients

Impact of Aggressive Versus Moderate Glycemic Control on Clinical Outcomes Following Coronary Artery Bypass Graft Surgery in Diabetic Patients

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00576394
Enrollment
108
Registered
2007-12-19
Start date
2006-10-31
Completion date
2015-06-30
Last updated
2015-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glycemic Control

Keywords

Glucose, Insulin

Brief summary

entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control (120-180mg/dl) will further improve outcomes.

Detailed description

150 diabetic patients will be randomized to achieve aggressive glycemic control (80-120mg/dl) vs moderate control (120-180mg/dl) using intravenous insulin infusions beginning at anesthetic induction and continuing for 18 hours following surgery.

Interventions

DRUGIV Insulin drip

IV insulin drip at 100units insulin in 100ml saline designed to keep blood glucose between 120-180mg/dl

DRUGInsulin

IV insulin drip to keep serum glucose between 80-120mg/dl.

Sponsors

Eli Lilly and Company
CollaboratorINDUSTRY
American Heart Association
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* All diabetic patients undergoing Coronary Bypass Surgery

Exclusion criteria

* Patients with hepatic and renal failure

Design outcomes

Primary

MeasureTime frame
Incidence of Hypoglycemia24 hours following surgery

Secondary

MeasureTime frame
free fatty acid levels24 hours following surgery

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026