Optimal Vitamin D Administration
Conditions
Keywords
vitamin D, seasonal variation, PTH, bone markers
Brief summary
The aim of this study is to compare oral vitamin D supplementation administered in two different ways, namely either twice a day (800IU/d, 292000IU/y) or three times a year (97333IU every 4 months, 292000IU/y) in elderly women in combination with daily supplementation of calcium 1 gram. We will 1)compare the blood concentrations of 25 OH vitamin D in the two treatment groups amd monitor if a sufficient and safe concentration of 25OH D in blood can be maintained with these two treatments.2) Find out seasonal variation in vitamin D concentrations in these treatments. 3) Find out safety of these treatments
Interventions
DIETARY_SUPPLEMENTvitamin D twice daily
Kalsipos-D, vitamin D3 400 ID/tbl, 2 tbl/day for one year
DIETARY_SUPPLEMENTVitamin D3 oil three times in a year
Vigantol oil , D3 20000IU/ml, 4.9 ml every four months for one year
Sponsors
Päivikki and Sakari Sohlberg Foundation, Finland
Lilly Foundation
University of Helsinki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
70 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Females * 70-80 years * Living in the community
Exclusion criteria
* Renal disease * Diseases that contraindicate vitamin D supplementation * Medications affecting bone * Malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood 25 OH D vitamin concentrations | 8 times during the year |
Secondary
| Measure | Time frame |
|---|---|
| serum calcium, 24-hour calcium excretion in urine, creatinine clearance | 8 times during the year |
Countries
Finland
Outcome results
None listed