Polycystic Ovary Syndrome
Conditions
Keywords
pco, simvastatin, ivf, embryo transfer
Brief summary
The purpose of this study is to determine whether simvastatin is effective in the improvement of IVF-ICSI outcome in Pcos patients.
Detailed description
simvastatin reduces cardiovascular risks by improving hypercholesterolemia, reducing vascular smooth muscle proliferation, ameliorating inflammation, limiting theca-interstitial proliferation & decreasing steroidogenesis (production of progesterone & testosterone).Polycystic ovary syndrome (pcos) is associated with increased cardiovascular risks and is characterized by ovarian theca-interstitial hyperplasia& hyperandrogenism .This study will test the hypothesis that simvastatin improves biochemical parameters& IVF-ICSI outcome in Pcos patients.
Interventions
DRUGSIMVASTATIN
20 mg/day,po,for two months until the day of hCG injection placebo pills as like as simvastatin will be used
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Pcos patients * Age \<40 years * FSH\<10 IU/L
Exclusion criteria
* Endometriosis grade 3 &4 * History of tubal surgery * Hydrosalpinx * History of mellitis diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ivf-et outcomes | 14-20 days |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical parameters baseline and 8weeks Biochemical parameters | baseline and 8weeks |
Countries
Iran
Outcome results
None listed