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Prospective Analysis and Comparison of Stress Echo to Real-Time Myocardial Contrast Stress Echo

Prospective Analysis and Comparison of Conventional Stress Echocardiograms and Real-Time Myocardial Contrast Stress Echocardiogram; for Bristol-Myers Squibb Medical Imaging: The Definity RT-P During DSE Database

Status
NO_LONGER_AVAILABLE
Phases
Unknown
Study type
Expanded Access
Source
ClinicalTrials.gov
Registry ID
NCT00575549
Enrollment
Unknown
Registered
2007-12-18
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Evaluation of Troponin I Levels

Brief summary

The purpose of this study is to prospectively analyze and compare conventional stress echocardiograms and real-time myocardial contrast stress echocardiograms; and to determine the effect of contrast agents used during real-time myocardial contrast stress echocardiograms on serum troponin I levels.

Detailed description

To compare two different stress echocardiograms (conventional Stress echocardiograms or Real-time Myocardial Contrast Stress Echocardiograms) that are in routine clinical use. The information, including the digital images that are collected during the stress tests is used to determine if the usse of specialized imaging techniques and ultrasound contrast can better detect blockage in blood flow to the heart and predict how patients outcome may be affected by this detection of a blockage.

Interventions

OTHERDobutamine: Perflutren Lipid Microsphere

Dobutamine with starting dose of 10 micrograms/kg/min and increased gradually to a maximum dose of 50 micrograms/kg/min Definity will be infused continuously at a rate of 4mL/min

Sponsors

Bristol-Myers Squibb
CollaboratorINDUSTRY
University of Nebraska
Lead SponsorOTHER

Eligibility

Sex/Gender
ALL
Age
19 Years to No maximum

Inclusion criteria

* Male or female * Age \> 19 years * Scheduled for a stress echocardiography * Are conscious and coherent, and able to communicate effectively with trial personnel * For troponin evaluation, only hospitalized patients who had a troponin level drawn in the morning of and prior to stress echocardiogram will be included.

Exclusion criteria

* Pregnant and breast feeding women are excluded from participation because of the possibility of a bias as CSE is routinely used in pregnant patients secondary to lack of human studies to determine the fetal risk of use of Definity. * Age \< 19 years old * Known or suspected hypersensitivity to ultrasound contrast agents or other drugs used for the study * Possibility that potential subject may be pregnant * Studies where RT-MCE was specifically requested by the ordering physician

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026