Breast Neoplasms
Conditions
Keywords
Sevoflurane, Isoflurane, Breast tumor, Anesthesia
Brief summary
Generally, benign breast tumors are excised under the local anesthesia. But such action was so invasive that every patient would experience the physiological and psychological stimuli unavoidably. Sevoflurane was advised as a better inhalational anesthesic for its easy come,easy go property during short-lasting operations than isoflurane. We purposed that sevoflurane would be a superior anesthesic for benign breast tumor excision than isoflurane with relative less alteration in hemodynamics, less postoperative side effects and easily-control the depth of anesthesia.
Interventions
DRUGSevoflurane
3-6% sevoflurane inhaled for anesthesia induction, and 2-3% sevoflurane was used to maintain the anesthesia till the end of the operation.
DRUGIsoflurane
3-6% isoflurane inhaled for anesthesia induction, and 2-3% isoflurane was used to maintain the anesthesia till the end of the operation.
Sponsors
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* Chinese * Diagnosed benign breast tumor patients * 18-64 yrs
Exclusion criteria
* Allergic to any interventional drugs * Organic dysfunction * Long-lasting PACU staying
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of induction, maintenance and resuscitation | 0h to the end of the operation |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamics; Postoperative side effects; | 0h to 24h after the end of the operation |
Countries
China
Outcome results
None listed