Erectile Dysfunction
Conditions
Keywords
ED, Erectile Dysfunction
Brief summary
The specific aim of this pilot study is to describe the angiographic prevalence and pattern of internal pudendal artery (and associated inflow vessel) atherosclerosis in patients with erectile dysfunction who are non-responsive to PDE-5 inhibitors (i.e., Viagra) who are referred for clinically-indicated cardiac catheterization.
Detailed description
The specific aim of this study is to determine if the deep penile arteries can be seen angiographically from the iliac arteries to delineate penile vasculature. Significant obstructive atherosclerotic disease of the deep penile arteries may be present in impotent males. The etiology of erectile dysfunction is multifactorial and may involve vascular disease, endocrine disorders, neurologic disease, prescription medications, psychological issues and/or trauma in any given patient. Vascular disease in patients with erectile dysfunction may be due to trauma, congenital anomalies, or atherosclerosis.
Interventions
None listed
Sponsors
University of California, Davis
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male patients * at least 50 years * erectile dysfunction * dissatisfaction with their use of a phosphodiesterase-5 inhibitor * coronary artery disease (or at risk for coronary artery disease) * undergoing diagnostic cardiac catheterization or patients with peripheral vascular disease undergoing peripheral arteriography
Exclusion criteria
* Patients who respond favorably to phosphodiesterase-5 inhibitors * known non-vascular etiologies of their erectile dysfunction * probable neurogenic erectile dysfunction due to radiation injury, surgery, or transurethral resection of the prostate * calculated GFR \< 60 ml/min/1.73 m2 will also be excluded * disease that necessitates complex percutaneous intervention will be excluded per the investigators discretion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Distal aortography with iliofemoral run-off will be performed to evaluate disease in the common and internal iliac arteries. | During Procedural Cath |
Secondary
| Measure | Time frame |
|---|---|
| Selective angiography of the internal pudendal artery (and accessory pudendal artery if present) will be performed bilaterally. | During Procedural Cath |
| Intra-arterial nitroglycerin (or papaverine or tolazoline if nitroglycerin is contraindicated) will be used to facilitate angiographic visualization of the internal pudendal and penile arteries. | During Procedural Cath |
Outcome results
None listed