Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00573599

Enrollment

Registered

2007-12-14

Start date

2007-02-28

Completion date

2007-05-31

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Migraine Headache

Keywords

Migraine, Emergency, imitrex, prochlorperazine, Acute Migraine Headache in the Emergency Department

Brief summary

ED patients with acute migraine will be randomized to either prochlorperazine and Bendaryl OR imitrex. VAS for pain will be monitored, along with side effects. Primary outcome measure is improvement in pain scales between the groups.

Interventions

DRUGprochlorperazine and benadryl IV

prochlorperazine and benadryl IV, saline subQ

DRUGImitrex SubQ, saline IV

Imitrex SubQ, saline IV

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Acute migraine headache

Exclusion criteria

* Pregnant * Hypertension * Chest pain * \< 18 * Allergy to any of the meds

Design outcomes

Primary

Measure	Time frame
Difference in pain measured by VAS	80 min

Secondary

Measure	Time frame
Degree of sedation, nausea, akathisia	80 min

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026