Metabolism of the Insecticide Permethrin

CCRC:Identification and Development of Biological Markers of Human Exposure to the Insecticide Permethrin

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00572884

Enrollment

Registered

2007-12-13

Start date

2006-02-28

Completion date

2007-11-30

Last updated

2007-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolism, Pharmacokinetics

Keywords

permethrin, pyrethroid, pharmacokinetics, metabolism, accelerator mass spectrometry, human exposure

Brief summary

Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.

Detailed description

Permethrin is applied to the forearm of the subject and remains for 8 hours. The exposed area is then washed with soap and water several times. 24 hour urine samples are collected at daily intervals for 192 hours. Blood and saliva samples are taken at pre-dose, 1, 3, 6, 9 12, 24, 48, 72, 96, 120, 144, 168 and 192 hours. Subjects must return to the clinic daily to drop off urine collections and have blood and saliva samples taken.

Interventions

OTHERpermethrin insecticide

25 mg neat carbon-14 labelled permethrin applied dermally in isopropyl alcohol, once for 8 hours containing 1 microcurie of carbon-14

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* self-report healthy adult men and premenopausal women

Exclusion criteria

* unusual alcohol, drug, cigarette use for last 3 years * unusual exercise program for last 3 years * under the care of a physician for a disease * participated in any radioactive drug study * pregnant * lactating * people who rely more on their arm due to illness or injury * people with neurological or musculoskeletal diseases * use of permethrin in the last 6 months * people who apply pesticides as their primary occupation

Design outcomes

Primary

Measure	Time frame
Concentration of individual metabolites in urine	192 hours

Secondary

Measure	Time frame
total carbon-14 in serum	192 hours
Total carbon-14 in saliva	192 hours
Total carbon-14 in urine samples	192 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026