Oestrogen Withdrawal in Hypopituitary Women

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00572390

Enrollment

Registered

2007-12-13

Start date

2001-01-31

Completion date

2002-02-28

Last updated

2007-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypopituitarism

Brief summary

By exploring hormonal status in hypopituitary women during oestrogen treatment and without estrogen substitution the influence on sexhormones and organ function is estimated.

Detailed description

38 hypopituitary women were examinined twice. During oestrogen treatment and after 1 month estrogen withdrawal. A control group of healthy women were examined once.Antropometric data and hormonal parameters were collected.

Interventions

DRUGoestrogen

Cyclic oestrogen substitution therapy

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Hypopituitarism

Design outcomes

Primary

Measure	Time frame
androgens, IGF-I, body composition, liver enzymes,	1 month

Secondary

Measure	Time frame
Grehlin, adiponection, leptin	1 month

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026