to Compare the Effect of Two Types of IOLs, on the Incidence of Cystoid Macular Edema, After Cataract Surgery
Conditions
Keywords
macula edema, intraocular lens, prospective randomized parallel clinical design
Brief summary
To compare the effect on blood retinal barrier disruption 3 and 12 months after implantation of either a blue light filtering intraocular lens(blue-filtering IOL) or an ultraviolet light filtering intraocular lens(UV-filtering IOL).
Detailed description
The following parameters were measured for evaluation of blood retinal barrier disruption. * the incidence of macular leakage by fluorescence angiography (FA) * the mean fluorescein concentration in the vitreous by fluorophotometry (VFP) * the thickness of the macula by optical coherence tomography (OCT) Results * the incidence fo macular leakage decreased significantly from 24%(3 months) to 5% (12 months) in the blue-filtering IOL group (P\<0.05), and was significantly lower compared with the UV-filtering IOL group at 12 months. * the VFP significantly decreased in both group from 3 to 12 months. * the OCT decreased from 175 (3 months) to 166 um (12 months) in the blue- filtering IOL group.
Interventions
PROCEDUREintraocular lens implantation
Intraocular lens implantation
Sponsors
Showa University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* cataract patients * All eligible for intraocular lens implantation
Exclusion criteria
* Patients had undergone an intraocular operation * Patients had hypertensive retinopathy * Patients had diabetic retinopathy * Patients had ange-related macular degeneration * no observable fundus * The cataract operation was more than 30 minutes in duration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure FA, VEP and OCT. | At 3 and 12 months after IOL implantation |
Countries
Japan
Outcome results
None listed