Depression, Traumatic Brain Injury
Conditions
Keywords
Traumatic brain injury, Depression, Exercise
Brief summary
We proposed to examine the effect of an aerobic exercise intervention on depression in persons with Traumatic Brain Injury (TBI). We will compare persons with chronic brain injury who are assigned to receive the exercise intervention with those in the control group to determine the effect of exercise on levels of depression and specific symptoms related to depression including anxiety, pain, sleep, and cognition. In addition, the effect of exercise on activity, participation level, and quality of life will be examined. HYPOTHESES: 1. Participation in an aerobic exercise intervention will decrease the severity of depression in persons with chronic TBI. 2. Participation in an aerobic exercise intervention will lead to improvements in negative symptoms associated with depression including anxiety, insomnia, pain, and impaired cognitive functioning. 3. Participation in an aerobic exercise intervention will be related to improvements in activity and participation for patients with TBI. 4. Participation in an aerobic exercise intervention will lead to improvements in perceptions of quality of life.
Interventions
BEHAVIORALAerobic exercise
A supervised aerobic exercise program occurred weekly for 30 minutes with a 15 minute warm-up and a 15 minute cool down. A half hour educational session on aspects of exercise and overcoming barriers to exercise was also instituted.
BEHAVIORALNo exercise
Controls were wait-listed for the exercise program during the 10 week study period.
Sponsors
University of Washington
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Traumatic brain injury 1-5 years prior to enrollment * Current depression as measured by a score of 5 or greater on the depression portion of the Physician Health Questionnaire (PHQ). * Sufficient cognitive ability to maintain participation in the study * Sufficient English language ability to allow participation without an interpreter
Exclusion criteria
* Current suicidal ideation with intent or plan * Currently pregnant * History of significant cardiovascular or respiratory disease * History of significant cardiovascular or respiratory disease * Physical barriers to the use of standard aerobic exercise equipment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Depression Inventory | 10 week |
Countries
United States
Outcome results
None listed