Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema

Effectiveness of Tiotropium to Maintain Inspiratory Capacity Against Metronome Paced Hyperventilation Induced Dynamic Hyperinflation in COPD Patients With Lung CT Scored Emphysema

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00570544

Enrollment

Registered

2007-12-11

Start date

2004-08-31

Completion date

2005-08-31

Last updated

2008-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Emphysema

Keywords

copd, emphysema, tiotropium, lung function, dynamic hyperinflation

Brief summary

To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.

Detailed description

We will analyze post hoc, data that was previously published: Gelb AF et al.Chest 2006;131:690-695. We have shown that tiotropium increases resting inspiratory capacity thereby providing lung volume protection against metronome paced hyperventilation induced dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb AF et al:Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic hyperinflation with extent of lung CT scored emphysema.

Interventions

DRUGtiotropium

18ug capsule daily for 30 days

Study design

Observational model

CASE_CROSSOVER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 85 Years

Healthy volunteers

Inclusion criteria

* moderate to severe copd

Exclusion criteria

* unable to tolerate tiotropium * unable to perform metronome paced hyperventilation induced dynamic hyperinflation

Design outcomes

Primary

Measure	Time frame
Correlate tiotropium induced increase in inspiratory capacity (IC)and FEV 1 with extent of emphysema as scored by lung CT.	After 30 days and 1.5hr of tiotropium

Secondary

Measure	Time frame
Correlate decrease in IC and FEV 1 following dynamic hyperinflation with underlying emphysema.	After 30 days and 1.5hr of tiotropium

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026