Myocardial Injury
Conditions
Keywords
myocardial protection, pharmacological preconditioning, volatile anesthetics, myocardial injury following CABG surgery
Brief summary
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.
Interventions
DRUGSevoflurane
1 MAC Sevoflurane will be given either continuously after induction of anesthesia until initiation of cardiopulmonary bypass or will be repetitively washed in and out twice before initiation of cardiopulmonary bypass.
Sponsors
Department of Anaesthesiology and Intensive Care Medicine
Abbott
University Hospital Schleswig-Holstein
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients schedulded to undergo CABG surgery * Age 18 to 80 years * Ejection fraction \> 40%
Exclusion criteria
* Emergency cases * Diabetes * Not able to give informed consent * Ejection fraction \< 40%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial cell damage as assessed by plasma levels of Troponin T | from induction of anesthesia until hospital discharge |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay on the ICU and in the hospital | from hospital admission until hospital discharge |
Countries
Germany
Outcome results
None listed