Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00568724

Enrollment

Registered

2007-12-06

Start date

2007-11-30

Completion date

2012-01-31

Last updated

2012-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ureteral Obstruction

Keywords

Hydronephrosis, Ureteral obstruction

Brief summary

The purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (UUO) and to elucidate the pathophysiology of UUO.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

3 Months to 15 Years

Healthy volunteers

Yes

Inclusion criteria

* Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction. * Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain.

Exclusion criteria

* Bilateral hydronephrosis * Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs. * Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections \< 6 months. * Neurogenic bladder dysfunction. * GFR \< 40 % standardized to age. * Non-compliance. Linguistic difficulties.

Design outcomes

Primary

Measure	Time frame
Urinary cytokines	1 year

Countries

Denmark

Outcome results