Scrub Typhus
Conditions
Keywords
Doxycycline,, Rifampin, Scrub typhus.
Brief summary
New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others. In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.
Interventions
DRUGrifampin
a 5-day course of daily 600-mg doses of rifampin
DRUGdoxycycline
a 5-day course of 100 mg bid doses of doxycycline
Sponsors
Dong-Min Kim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Inclusion criteria were: * Adults aged 18 years or older * A fever of higher than 37.5°C * The concurrent presence of eschar or a maculopapular skin rash; and the clear presence of more than two symptoms such as headache, malaise, myalgia, coughing, nausea and abdominal discomfort. * Patients were hospitalized at Chosun University Hospital in Kwangju, Korea or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.
Exclusion criteria
The
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end point was the fever clearance time | 4 years |
Secondary
| Measure | Time frame |
|---|---|
| The secondary end point was evaluated according to the following definitions. Cure , Failure, Relapse | 4 years |
Countries
South Korea
Outcome results
None listed