Healthy Volunteer, Neurodegenerative Diseases
Conditions
Keywords
Visuomotor Integration, Visual Attention, Eye Movements, Reaction Time, Natural History, Saccades, Healthy Volunteer, HV
Brief summary
Background: * The relation between eye movement and brain function is a subject of interest to the National Eye Institute. * By comparing eye movement in healthy volunteers to research conducted on patients who have difficulty moving their eyes, the National Eye Institute hopes to develop and improve diagnostic procedures for people with eye diseases. Objectives: -The purpose of this study is to understand how we see visual patterns and how we move our eyes to see. Eligibility: * Normal volunteers: * must have no serious illnesses and must be 18 years of age or older * are able to follow directions and pay attention to visual stimuli and respond as appropriate * individuals with a history of eye or brain diseases, or previous eye or eye muscle surgery, are not allowed to participate in this study. Individuals who are currently using eye medications also are not eligible for the study. * Patients: * who are 18 years of age or older * are able to follow directions and pay attention to visual stimuli and respond as appropriate Design: * Participants will visit the National Eye Institute outpatient clinic for examination and testing. * Participants will be screened with a medical history and eye examination (including eye pressure and eye movement tests). * Participants with healthy eyes will participate in eye movement testing experiments: * One or more sessions lasting less than three hours each. * Eye movements will be recorded with a video/infrared camera system. * For the majority of the studies done under this protocol, only one or two sessions will be required. A few studies recording very small eye movements will require three or more sessions.
Detailed description
Study Description: This natural history study will investigate eye movements and other responses to visual stimuli in normal individuals (normal volunteers) and patients. Normal adult volunteers will be recruited and will undergo an eye exam to assure that there are no visual system problems. . Volunteers will be studied in one or more sessions where eye movement, verbal, or hand movement responses are recorded in response to visual stimuli. Patients with diseases affecting the oculomotor or visual systems will also be recruited to help us better understand these systems and to help characterize their specific disease. Objectives: The objective is to study normal volunteers and patients for eye movement and other responses to visual stimuli with the goal of better understanding human vision and neural control of eye movements. Endpoints: The primary outcome measure is eye movement and other responses to visual stimuli.
Interventions
None listed
Sponsors
National Eye Institute (NEI)
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 120 Years
Healthy volunteers
Yes
Inclusion criteria
* INCLUSION CRITERIA: Inclusion Criteria for Normal Volunteers: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Participant must be a volunteer with no ocular, visual, or oculomotor problems. 2. Participant must be 18 years old or older. 3. Participant must be able to follow directions and actively pay attention to visual stimuli and respond as appropriate. 4. For studies which use the contact lens, participant must be able to tolerate a contact lens in either one or both eyes. Inclusion Criteria for Patients: In order to be eligible to participate in this study, an individual must meet all of the following criteria 1. Participant must be 18 years old or older. 2. Participant must be able to follow directions and actively pay attention to visual stimuli and respond as appropriate. 3. For studies which use the contact lens, participant must be able to tolerate a contact lens in either one or both eyes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| eye movement/responses to visual stimuli | one to many times depending if normal volunteer or patient and the number of trials required to achieve clean data for small eye movements. | Analysis of eye movements to characterize basic processes (normal volunteers) and to judge disease progress (in patients) |
Countries
United States
Outcome results
None listed