Sympathetic Innervation of the Heart and Cardiac Resynchronization Therapy(CRT)

Identification of the Role of Sympathetic Innervation in Heart Failure Patients Treated With Cardiac Resynchronization Therapy. A Pilot Study

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00567645

Acronym

PET-CRT

Enrollment

Registered

2007-12-05

Start date

2007-07-31

Completion date

Unknown

Last updated

2016-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Heart Failure, Sympathetic Innervation

Brief summary

The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT). And to assess whether response to CRT coincides with restoration of regional sympathetic innervation.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Indication for CRT * Stable optimal medication * Non ischemic cardiomyopathy

Exclusion criteria

* Age less then 18 years * Previous CRT * Clinically relevant valvular heart disease or coronary artery disease * Acute or chronic infection * Untreated clinical hypo- or hyperthyroidism or \< 3 months euthyroidism * Uncontrolled hypertension, defined as a systolic blood pressure \> 160 mm Hg and/or a diastolic blood pressure \> 95 mm Hg * A concurrent medical condition (i.e. alcohol or drug abuse or a severe progressive extra cardiac disease or M. Parkinson) or is unlikely to comply with the protocol * Participation to a previous protocol involving radioactivity in the past year * Pregnancy

Design outcomes

Primary

Measure	Time frame
sympathetic innervation in patients with chronic heart failure (CHF)	6 months

Secondary

Measure	Time frame
NYHA class Echocardiographic parameters: LVEDD, LVESD, LVEF, LVESV,IVMD, and septal to lateral delay Hospitalization for heart failure Maximal oxygen consumption NT pro-BNP changes	6 months

Countries

Netherlands

Outcome results