Pulmonary Arterial Hypertension
Conditions
Keywords
PAH, Biomarkers, MIF, BNP, 6 Minute Walk (6MW)
Brief summary
The investigators hypothesize that baseline plasma brain natriuretic peptide (BNP) and migration inhibitory factor (MIF) levels are surrogate markers of clinical severity of PAH and that changes in plasma brain natriuretic peptide (BNP) and MIF levels pre and post exercise.
Detailed description
As above
Interventions
OTHERBlood draw
Venous and Arterial Blood draw samples; 6 Minute Walk test
Sponsors
Northwell Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Confirmed diagnosis of PAH, based on currently accepted gold standard for Right Heart Catheterization. * Patients with mean artery pressure of greater that 25 mm Hg at rest or 30mm Hg during exercise with pulmonary capillary wedge pressure less than 18mm Hg on right heart catheterization.
Exclusion criteria
* Significant left heart disease or renal insufficiency (serum creatinine \> 1.5 mg%).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess the correlation of plasma/arterial BNP and MIF levels pre/post with the 6 Minute walk test distance and echocardiographic parameters as surrogate markers of severity of PAH. | 2 year |
Secondary
| Measure | Time frame |
|---|---|
| To determine if changes in plasma/arterial MIF levels pre/post 6MW test are due to MIF released from the lungs | 2 year |
Countries
United States
Outcome results
None listed