Postpartum Depression
Conditions
Keywords
postpartum depression, thyroxine, thyroid antibodies, thyroid stimulating hormone, Edinburgh Postnatal Depression Scale (EPDS)
Brief summary
Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.
Detailed description
This small pilot study was an attempt to corroborate a relationship between quantified mood and thyroid measures, using the numerical scores obtained from a common depression screen, the Edinburgh Postnatal Depression Scale (EPDS), as a continuum. Mood scores were compared with presence of thyroid autoantibodies and plasma concentrations of free T4 and TSH.
Interventions
None listed
Sponsors
Oklahoma State University Center for Health Sciences
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Over 18 years of age * In third trimester of pregnancy when recruited * Negative for the following drugs detected by a urine drug screen: * Amphetamines * Barbiturates * Benzodiazepines * Cocaine * Opiates * Phencyclidine metabolites (PCP), and tricyclic antidepressants * Vaginal delivery * Screened negative for major depressive disorder on the Edinburgh Postnatal Depression Scale (EPDS) at her prenatal enrollment in the study * Receiving a score of 12 or lower out of a possible 30
Exclusion criteria
* Under age 18 * Positive for any of the following drugs: * Amphetamines * Barbiturates * Benzodiazepines * Cocaine * Opiates * Phencyclidine metabolites (PCP), and tricyclic antidepressants * Cesarean delivery * EPDS score over 12 at prenatal screening test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical score on the Edinburgh Postnatal Depression Scale | seven weeks |
Countries
United States
Outcome results
None listed