Hepatitis C, Hepatitis, Viral, Human, Nutritional Status
Conditions
Keywords
Agaricus blazei (Murrill) ss. Heinemann,, Hepatitis C, Nutritional status, Liver Function Tests, Antiviral Agents
Brief summary
The aim of the study was to verify the influence of Agaricus blazei (Murrill) ss. Heinemann (A. blazei) on the evolution of nutritional state and liver function in hepatitis C patients.
Detailed description
Ten patients were studied (5 - GI - not taking A. blazei - and 5 - G2 - taking A. blazei), from both sexes, with positive Anti-VHC and a healthy nutritional state, admitted into in the viral hepatitis ward. Diagnosis and treatment for hepatitis C concurred with the regulations of the Ministry of Health and nutritional evaluation was performed in 3 moments according to anthropometrical, bioimpedance, biochemical and dietary standards, with duration of 6 months. The consumption of A. blazei (10g/day) in dehydrated powder was concomitant with antiviral therapy (conventional or pegylated interferon associated with ribavirin) with duration of 5 months.
Interventions
DIETARY_SUPPLEMENTAgaricus blazei (Murrill) ss. Heinemann (sun mushroom)
Agaricus blazei powder, 10 grams/day, for 5 months
Sponsors
UPECLIN HC FM Botucatu Unesp
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
24 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* To have been informed and signed adequately the free and clarified assent * Initiating the anti-viral treatment (interferon or pegylated interferon associate the ribavirin) * Age: 24-70 years * Gender :both the gender * Race : all races * To present serology positive to the anti-VHC ELISA * To present genotype type 1,2,or 3 * Body mass index- \>18,5 e \< 35kg /m2 * Conditions full to the ORAL ingestion
Exclusion criteria
* Don't agree to the project or don't have signed the term of clarified free assent * Restriction for oral ingestion * The existence of surface of antigen of the hepatitis B virus(Ag HBs) * The existence of antibody for the human immunodeficiency virus * To be enclosed in another project of research or form of treatment * Pregnant women * Suckles * Cirrhosis * Patients with hepatitis auto-imune.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure: influence of Agaricus blazei (Murrill) ss. Heinemann on the evolution of nutritional state and liver function in hepatitis C patients. Time Frame: six months | Time Frame: six months |
Countries
Brazil
Outcome results
None listed