Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00564408

Enrollment

Registered

2007-11-28

Start date

2007-08-31

Completion date

2009-02-28

Last updated

2009-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache

Brief summary

The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

Detailed description

To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

Interventions

DRUGCarbachol

3 microgram per kg bodyweight infused intravenously

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Migraine without aura * Weight 50-100 kg

Exclusion criteria

* Other significant diseases * Migraine 5 days prior to experiment

Design outcomes

Primary

Measure	Time frame
Headache response after Carbachol infusion	1 day after infusion

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026