Mechanism and Efficacy of Rehabilitation Approaches

Mechanisms and Long-term Effects of Separate vs. Coupled Rehabilitation Approaches After Stroke

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00564005

Enrollment

Registered

2007-11-27

Start date

2008-01-31

Completion date

2010-12-31

Last updated

2015-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular Accidents

Keywords

stroke rehabilitation, cortical reorganization, kinematic analysis

Brief summary

Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity principles and sound motor control theories.

Detailed description

Comparisons of constraint-induced therapy (CIT) vs. bilateral arm training (BIT)vs. combined therapy were made. Stroke patients will receive one of these three approaches and be evaluated pre- and post-treatment. the treatment will last 3 weeks and 5 days per week. The evaluation will include clinical measures of motor function, ADL, and quality of life, kinematic performance, and activation patterns of cortex.

Interventions

OTHERConstraint-induced therapy (CIT)

restraint of the unaffected arm and practice of the affected arm

OTHERBilateral arm training (BAT)

bilateral symmetric, repetitive arm training

OTHERCombined therapy (CT)

combined different treatment approaches

BEHAVIORALControl intervention

Conventional treatment program

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

* a first-ever clinical cerebrovascular accident patients * at least 6 months post-stroke onset * premorbid right-hand dominance * demonstration of Brunnstrom stage III of the affected upper extremity * no excessive spasticity in the joints of the affected upper extremity

Exclusion criteria

* a score of less than 24 on the Mini Mental State Exam * poor physical conditions that would interfere with participation * excessive pain in any joint that might limit participation

Design outcomes

Primary

Measure	Time frame
Cortical reorganization and kinematic analysis	2008-2010

Secondary

Measure	Time frame
clinical measures at the impairment, activity, participation levels	2008-2010

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026