Carcinoma, Squamous Cell, Nasopharyngeal Neoplasms
Conditions
Keywords
Nasopharyngeal Carcinoma, T3-4N0-1M0
Brief summary
To test the therapeutic ratio of accelerated radiotherapy and/or chemotherapy on locally advanced nasopharyngeal carcinoma.
Interventions
Sponsors
The Hong Kong Nasopharyngeal Cancer Study Group
Hospital Authority, Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 70 Years
Inclusion criteria
* Undifferentiated or non-keratinizing carcinoma * Tumor staged as T3-4 AND N0-1 * No evidence of distant metastasis (M0) * Performance status: 0-2 * Marrow: WBC \>= 4 and platelet = 100 * Renal: creatinine clearance = 60 * Informed consent
Exclusion criteria
* WHO type I squamous cell carcinoma or adenocarcinoma * Age \>= 70 * Palliative intent or tumor extent mandating AP opposing facio-cervical fields * Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for 5 years * Previous radiotherapy (except non-melanomatous skin cancers outside the intended RT treatment volume * Previous chemotherapy * Patient is pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Failure free survival rate | 5-year |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival rate | 5-year |
| Disease-specific survival rate | 5-year |
| Complication-free rates | 5-year |
Countries
China
Outcome results
None listed