Heart Failure, Cheyne Stokes Respiration
Conditions
Keywords
heart failure, cheyne stokes respiration, adaptive servo ventilator
Brief summary
An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.
Detailed description
Chronic heart failure (HF) is one of the most important public health problems in cardiovascular medicine. Several patients with chronic heart failure also has Cheyne Stokes respiration pattern. Earlier studies have shown that this respiration pattern improves with Adaptive servo ventilator. We wish to investigate wether this leads to improved cardiac function.
Interventions
DEVICEASV
Adaptive servo ventilator
OTHERwithout Autoset CS2
without Autoset CS2
Sponsors
ResMed
University of Oslo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Ejection fraction \<40% * NYHA class III-IV * Optimized therapy with drugs * Cheyne stokes respiration pattern \> 25% while sleeping * Age \< 85 years * clinical stability the last month before inclusion.
Exclusion criteria
* CABG less then 6 months ago * PCI treatment less then 3 months ago * Unstable angina pectoris * Acute coronary syndrome less then 3 months ago * Stroke less then 6 weeks ago * Thoracal myopathy * Advanced COPD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ejection fraction (measured with echocardiography) and inflammatory markers | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| 6 minutes walking test Quality of life Changes in cathecolamines Altered frequency of arrythmias | 3 months |
Countries
Norway
Outcome results
None listed