Polytraumatism
Conditions
Brief summary
Interest of treatment of polytraumatisms with corticoids (hydrocortisone) for patient with relative adrenocortical insufficiency on frequency of nosocomial infection, and hemodynamic complications and organs injuries.
Interventions
DRUGhydrocortisone
200mg/jour (solution of 48mL), Day 1 to Day 4 100mg/jour (solution of 48mL), Day 5 50mg/jour (solution of 48mL), Day 6
DRUGNaCl
48mL from Day 1 to Day 6
Sponsors
Nantes University Hospital
Serb
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age superior of 15 years * Hospitalization in reanimation for polytraumatism (lesion of two organs with a vital risk) * SISS score more than 15 * Intubation for more than 48 hours. * Agreement of a family member * Patient with insurance
Exclusion criteria
* History of corticothérapies within 6 months * History of adrenocortical insufficiency. * Treatment by immunosuppressor * Immunodeficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nosocomial pneumopathy: radiological, clinical and bacteriological criteria | 28 days |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bacteremia, urinary infections, infections of the operatory sites, incidence of SDRA, organ dysfunction,mortality, etc. | 28 days |
| Incidence of nosocomial pneumopathy | Day 8 |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMahe Joachim, MD
Nantes University Hospital
Outcome results
None listed