Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks

Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks: A Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00562536

Acronym

DUC

Enrollment

296

Registered

2007-11-22

Start date

2007-11-30

Completion date

2010-11-30

Last updated

2007-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature Birth

Keywords

Umbilical cord clamping, Preterm infants, Randomized controlled trial, For women giving birth to singleton infants 32 weeks gestational age or less

Brief summary

The overall objective of the present study is to examine the effects of delayed umbilical cord clamping in preterm infants on neonatal outcomes using a prospective randomized controlled trial comparing immediate cord clamping (standard at present) with delayed cord clamping. Our specific aim is to determine if a 30 to 45 second delay in umbilical cord clamping improves neonatal outcome as assessed by a composite of intraventricular hemorrhage and late onset sepsis in preterm infants born between 24 and 32 weeks gestation. Secondary outcomes to be examined include improvements in the following: 1) lung function as assessed by oxygen dependency at 36 weeks corrected gestational age (CGA), 2) cardiovascular function as assessed by the need for volume expansion, inotropes, or clinically suspected PDA requiring intervention prior to discharge home, and 3) anemia as assessed by initial hemoglobin, need for transfusion during stay in the NICU, and number of transfusions.

Interventions

PROCEDUREUmbilical cord clamping

Delay of umbilical cord clamping 30 to 45 seconds

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

15 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Women in labour or with a plan for delivery at a gestational age between 24 0/7 to 32 0/7 weeks gestation. * Singleton pregnancy (Note: if pregnancy was a multiple gestation but demised occurred prior to 13 weeks, these patients can be included in study).

Exclusion criteria

* Moderate to life threatening fetal anomalies * Multiple live gestations at birth (e.g. twins, triplets, etc) * Intrauterine fetal demise * Previous participation * Stem cell collection

Design outcomes

Primary

Measure	Time frame
Primary Composite outcome of Intraventricular Hemorrhage and/or Late Onset Sepsis	3 years

Secondary

Measure	Time frame
Secondary outcomes include: 1) lung function 2) cardiovascular function and 3) anemia.	3 years

Countries

Canada

Contacts

Primary ContactKellie E. Murphy, MD MSc

kmurphy@mtsinai.on.ca416 586-8570

Backup ContactKelly Chu, MD

kelly.chu@utoronto.ca

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026