Irritable Bowel Syndrome
Conditions
Keywords
IBS, Diarrhea, Rome III
Brief summary
Probiotics may improve symptoms in IBS patients. The aim of this study is to test the efficacy of Lactobacillus FARCIMINIS in diarrhea predominant IBS patients according to Rome III criteria.
Detailed description
The aim of this study is to test the efficacy of Lactobacillus FARCIMINIS in diarrhea predominant IBS patients according to Rome III criteria.
Interventions
DIETARY_SUPPLEMENTLactobacillus FARCIMINIS
10.10 UFC of lactobacillus FARCIMINIS
DIETARY_SUPPLEMENTplacebo (starch)
Once daily
Sponsors
Association pour l'Etude des Fonctions Digestives
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Diarrhea predominant IBS * Less than 5-year duration * Pain intensity between 2 and 7 on VAS
Exclusion criteria
* Celiac disease * Antibiotic treatment within the 1-month period preceding inclusion * Digestive organic disease * Any severe non digestive organic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall subject's assessment | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Decrease in abdominal pain, stool form and consistency, modifications in intestinal permeability, modification in fecal serine protease activity, modifications in interleukin seric concentrations | 4 weeks |
Countries
France
Outcome results
None listed