Anorexia of Ageing
Conditions
Keywords
Anorexia of ageing, Anorexia of aging, Energy balance, Elderly
Brief summary
Over the past century life expectancy has risen rapidly. As a result, the proportion of elderly people continues to grow. Elderly people probably have an impaired regulation of energy balance (energy intake versus energy expenditure) whereby the underlying physiological mechanisms are not fully understood. The first objective of this study is to provide further evidence for an age-related failure to regulate energy balance in elderly. If the hypothesis of impaired regulation of energy balance in elderly is confirmed then the second objective becomes to elucidate the underlying physiological mechanisms of the age-related failure to regulate energy intake in elderly.
Interventions
OTHEREnergy restriction period
The experiment can be divided in 3 phases, namely (1) run-in phase, (2) energy restriction phase and (3) ad libitum food intake phase. Thus, for all participants the experiment consists of three subsequent phases.
Sponsors
Dutch Dairy Organization (NZO)
Wageningen University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* men * healthy * 20-40 and 65-85 years of age * normal weight * free-living in Wageningen and surrounding
Exclusion criteria
* anemia * diabetes * restrained eating * dementia * weight changes of \> 2 kg during the last 2 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy Intake Compensation | Average intake of energy during ad lib phase (9 days) | To assess energy intake compensation, we will assess average energy intake during the ad libitum food intake phase - which is the period after energy restriction- in young men and compare this to average energy intake in older men. Average energy intake is assessed by measuring total megajoule of energy intake during nine days of the ad lib phase, and then divide it by nine (MJ/day) |
Secondary
| Measure | Time frame |
|---|---|
| Appetite/Satiety Hormones and Questionnaires | Before and after the energy restriction period. |
| Gastrointestinal Function | Before and after the energy restriction period |
| Resting Energy Expenditure, Body Composition and Body Weight | Before and after the energy restriction period |
| Expression of Genes Involved in Energy Metabolism | Before and after the energy restriction period. |
Countries
Netherlands
Participant flow
Recruitment details
Subjects will be recruited by publishing advertisements in local newspapers and by sending out general e-mails to an e-mail list of persons who had indicated their interest in participating in studies of our university
Participants by arm
| Arm | Count |
|---|---|
| Young Men Young men: 20-40 years of age | 15 |
| Elderly Men Elderly men: 65-85 years of age | 17 |
| Total | 32 |
Baseline characteristics
| Characteristic | Elderly Men | Young Men | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 17 Participants | 0 Participants | 17 Participants |
| Age, Categorical Between 18 and 65 years | 0 Participants | 15 Participants | 15 Participants |
| Age, Continuous | 68 years INTER_QUARTILE_RANGE 1 | 24 years INTER_QUARTILE_RANGE 1 | 50 years INTER_QUARTILE_RANGE 1 |
| Region of Enrollment Netherlands | 17 participants | 15 participants | 32 participants |
| Sex: Female, Male Female | 0 Participants | 0 Participants | 0 Participants |
| Sex: Female, Male Male | 17 Participants | 15 Participants | 32 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 15 | 0 / 17 |
| serious Total, serious adverse events | 0 / 15 | 0 / 17 |
Outcome results
Primary
Energy Intake Compensation
To assess energy intake compensation, we will assess average energy intake during the ad libitum food intake phase - which is the period after energy restriction- in young men and compare this to average energy intake in older men. Average energy intake is assessed by measuring total megajoule of energy intake during nine days of the ad lib phase, and then divide it by nine (MJ/day)
Time frame: Average intake of energy during ad lib phase (9 days)
Population: completed (see publication)
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Young Men | Energy Intake Compensation | 1 MJ/day | Standard Deviation 1 |
| Elderly Men | Energy Intake Compensation | 1 MJ/day | Standard Deviation 1 |
Secondary
Appetite/Satiety Hormones and Questionnaires
Time frame: Before and after the energy restriction period.
Secondary
Expression of Genes Involved in Energy Metabolism
Time frame: Before and after the energy restriction period.
Secondary
Gastrointestinal Function
Time frame: Before and after the energy restriction period
Secondary
Resting Energy Expenditure, Body Composition and Body Weight
Time frame: Before and after the energy restriction period