Atherosclerosis, Chlamydia Infections, Coronary Artery Disease, Mycoplasma Infections
Conditions
Keywords
Atherosclerosis, Coronary artery disease, Chlamydia pneumoniae, Mycoplasma pneumoniae
Brief summary
To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes.
Detailed description
One hundred and twenty-six patients were divided into 4 groups: Acute Coronary Syndrome with ST-elevation, Non-ST-elevation, stable coronary artery disease, and individuals without coronary disease. Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured at baseline and after 6 months.
Interventions
OTHERblood sample analysis - mycoplasma and chlamydia antibodies
Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured by indirect immunofluorescence at baseline (24 hours of hospitalization) and after 6 months (follow-up).
Sponsors
University of Sao Paulo
Hospital de Base
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \>18 yrs * Males and females * Agreed to sign the informed consent
Exclusion criteria
* Refusal to sign the informed consent * Follow-up not possible * For the acute groups, time between the pain beginning and randomization \>24 hours * Active infections * Use of antimicrobial agents within the last 30 days * End-stage diseases with life expectancy \<6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Test the hypothesis that patients with acute coronary syndromes have higher levels of Chlamydia pneumonia and Mycoplasma pneumonia antibodies in comparison with patients with stable coronary artery disease or controls. | 6 months |
Outcome results
None listed